Medicine by Design funds transformational research in regenerative medicine. The following is a list of selected publications:
Mitrousis N; Tam RY, Baker AEG; van der Kooy D; Shoichet MS. Hyaluronic acid-based hydrogels enable rod photoreceptor survival and maturation in vitro through activation of the mTOR pathway. Advanced Functional Materials. 26:1975-85, Feb 2016.
Lipsitz, Y., Timmins, N., Zandstra, P. Quality cell therapy manufacturing by design. Nature Biotechnology. 34:393–400, Apr 2016.
Nakajima D, Cypel M, Bonato R, Machuca TN, Iskender I, Hashimoto K, Linacre V, Chen M, Coutinho R, Azad S, Martinu T, Waddell TK, Hwang DM, Husain S, Liu M, Keshavjee S. Ex vivo perfusion treatment of infection in human donor lungs. Am J Transplant. 16(4):1229‐37, Apr 2016.
Korytnikov R, Nostro MC. Generation of polyhormonal and multipotent pancreatic progenitor lineages from human pluripotent stem cells. Methods. 101:56‐64, May 2016.
Yuzwa S.A., Yang G., Borrett M., Clarke G., Cancino G.I., Zahr S.K., Zandstra P.W., Kaplan D.R., and Miller F.D. Proneurogenic ligands defined by modeling developing cortex growth factor communication networks. Neuron. 91, 988‐1004, Sept 2016.
Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman‐Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers‐Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G. Ectopic miR‐125a Expression Induces Long‐Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors. Cell Stem Cell. 19(3):383‐96, Sep 2016.
Rodrigues DC, Kim DS, Yang G, Zaslavsky K, Ha KC, Mok RS, Ross PJ, Zhao M, Piekna A, Wei W, Blencowe BJ, Morris Q, Ellis J. MECP2 is post-transcriptionally regulated during human neurodevelopment by combinatorial action of RNA-binding proteins and MiRNA. Cell Rep. 17(3):720-734, Oct 2016.
Rodenhizer D, Cojocari D, Wouters BG, McGuigan AP. Development of TRACER: tissue roll for analysis of cellular environment and response. Biofabrication. 8(4):045008, Oct 2016.
Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC. A 17‐gene stemness score for rapid determination of risk in acute leukaemia. Nature. 15;540(7633):433‐437, Dec 2016.
Lipsitz YY, Bedford P, Davies AH, Timmins NE, Zandstra PW. Achieving efficient manufacturing and quality assurance through synthetic cell therapy design. Cell Stem Cell. 20(1):13–17, Jan 2017.
Xu W, Huang M, Gappasov A, Azimi A, Sachewsky N, Morshead CM. Myelin basic protein regulates primitive and definitive neural stem cell proliferation from the adult spinal cord. Stem Cells. 35(2):485‐496, Feb 2017.
Moorthy SD, Davidson S, Shchuka VM, Singh G, Malek-Gilani N, Langroudi L, Martchenko A, So V, Macpherson NN, Mitchell JA. Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes. Genome Res. 27(2):246-258, Feb 2017.
McGaugh EC, Nostro MC. Efficient differentiation of pluripotent stem cells to nkx6-1+ pancreatic progenitors. J Vis Exp. (121), e55265, Mar 2017.
Altalhi A, Sun X, Sivak J, Husain M and Nunes SS. Diabetes impairs arterio‐venous specification in engineered vascular tissues in a perivascular cell recruitment‐dependent manner. Biomaterials. 119, 23‐32. Mar 2017.
Zulueta-Coarasa T, Fernandez-Gonzalez R. Tension (re)builds: biophysical mechanisms of embryonic wound repair. Mechanisms of Development. 144(Pt A):43-52, Apr 2017.
Zhou W., Mahshid SS, Wang W, Vallée‐Bélisle A, Zandstra PW, Sargent EH, Kelley SO. Steric Hindrance Assay for Secreted Factors in Stem Cell Culture. ACS Sensors. 28;2(4):495-500, Apr 2017.
Ortin-Martinez A, Tsai EL, Nickerson PE, Bergeret M, Lu Y, Smiley S, Comanita L, Wallace VA. A reinterpretation of cell transplantation: GFP transfer from donor to host photoreceptors. Stem Cells. 35(4):932-939, Apr 2017.
Wang MFZ, Hunter MV, Wang G, McFaul C, Yip CM, Fernandez- Gonzalez R. Automated cell tracking identifies mechanically oriented cell divisions during Drosophila axis elongation. Development. 144(7):1350-61, Apr 2017.
Shukla S, Langley MA, Singh J, Edgar JM, Mohtashami M, Zúñiga‐Pflücker JC, Zandstra PW. Progenitor T‐cell differentiation from hematopoietic stem cells using delta‐like‐4 and VCAM‐1. Nat Methods. 14(5):531-538, May 2017.
Mahou R, Zhang DKY, Vlahos AE, Sefton MV. Injectable and inherently vascularizing semi-interpenetrating polymer network for delivering cells to the subcutaneous space. Biomaterials. 131:27-35, Jul 2017.
Liran I. Shlush, Amanda Mitchell, Lawrence Heisler, Sagi Abelson, Stanley W. K. Ng, Aaron Trotman-Grant, Jessie J. F. Medeiros, Abilasha Rao-Bhatia, Ivana Jaciw-Zurakowsky, Rene Marke, Jessica L. McLeod, Monica Doedens, Gary Bader, Veronique Voisin, ChangJiang Xu, John D. McPherson, Thomas J. Hudson, Jean C. Y. Wang, Mark D. Minden, John E. Dick. Tracing the origins of relapse in acute myeloid leukaemia to stem cells. Nature. 547:104–108, Jul 2017.