Using state-of-the art sequencing technology, Medicine by Design-funded scientists have revealed how stem cells are able to generate new blood cells throughout our life, and how these same cellular mechanisms can evade chemotherapy to survive and cause relapse many years later.
Medicine by Design-funded researchers develop a new tool for scooping contents of individual cells from their local environment
Scientists can now select individual cells from their local environment & study their molecular contents. The new tool will enable a deeper study of stem cells and other rare cell types for diagnostics & therapy.
Medicine by Design-funded researchers re-engineer enzyme that could help reverse damage from spinal cord injury and stroke
New version is more stable than the protein that occurs in nature, and could lead to new treatments for reversing nerve damage caused by traumatic injury or stroke.
Medicine by Design-funded researchers develop cell injection technique that could help reverse vision loss
The technique could point the way toward new treatments with the potential to reverse forms of vision loss that are currently incurable.
Critical planning for regenerative medicine therapies needs to happen now to ensure smooth adoption into health system, paper urges
Data generation, evidence of clinical effectiveness, cost and social values among the key considerations
U of T and SickKids researchers demonstrate drug stimulation of neural stem cell repair leads to promising impact on treatment of childhood brain injury in survivors of brain cancer
Cross-species study shows that Type 2 diabetes drug metformin could change the way childhood brain injury is treated
Medicine by Design-funded team uses stem cells to grow functional blood vessel cells found in the liver
Discovery to provide insights into liver development and disease progression
A team of researchers led by scientists at the University of Toronto has delayed the onset of amyotrophic lateral sclerosis (ALS) in mice. They are cautiously optimistic that this research, which was funded in part by a Medicine by Design 2018 New Ideas Award, combined with other clinical advances, points to a potential treatment for ALS in humans.
Genome editing just got more versatile thanks to a new technology developed by Medicine by Design-funded investigators at U of T
Scientists can now edit multiple sites in the genome at the same time to learn how different DNA stretches co-operate in health and disease.
'We think we can really accelerate the field and its capacity to improve lives'
Accounting for sex differences could be key for the development of better treatments as drug shows promise for brain repair in females only
Finding inspiration from an unlikely source, a team led by Andras Nagy at Sinai Health System has an answer for one of the most pressing questions in cell therapy: how to ensure its safety
Medicine by Design researchers clear hurdles toward robust supply of stem cells for research and therapy
Paper identifies new combination of factors that allow scientists to grow stem cells in lab on much larger scale than previously possible
Medicine by Design-funded research could help answer fundamental biological questions and advance efforts to make organ-like structures
Researchers from Peter Zandstra's lab have developed new technologies that clear key barriers to developing a renewable source of cells for therapies.