Stem cell pioneer Gordon Keller, director of the University Health Network's McEwen Stem Cell Institute, leads a team of eight labs focused on harnessing the liver’s power to regenerate. Read more.
A Medicine by Design team is working on reprogramming brain cells — a strategy that has demonstrated brain repair in animal models of stroke. "Think of it as a bespoke strategy for brain repair,” says Maryam Faiz, one of the team's researchers. Read more.
Cristina Nostro, senior scientist at McEwen Stem Cell Institute, UHN, is a pioneer in developing insulin-producing cells as a cell therapy. She collaborates with UHN’s Sara Nunes Vasconcelos, a senior scientist who’s a vasculature, or blood vessel, expert. Together, they are developing a cell therapy for type 1 diabetes. Read more.
A team led by Andras Nagy, senior investigator at Sinai Health System, has been developing a method called cloaking to enable treatments for type 1 diabetes. The cloaking technology turns off certain genetic switches in the cells to avoid detection and rejection by the immune system. Read more.
A team led by Sunnybrook Research Institute’s Juan Carlos Zúñiga-Pflücker, is working on immune-engineering techniques to enable a treatment for type 1 diabetes. The team’s strategy is to finely tune the immune system to maintain a healthy system while not rejecting a therapeutic transplant. Read more.
Sarah Crome, a scientist at UHN, is working on an innovation that could have an impact on type 1 diabetes as well as the success of organ transplants. Her team is testing a new immune-cell therapy approach using a subset of immune cells with anti-inflammatory properties. Read more.
Michael Sefton, scientific director of Medicine by Design and University Professor at U of T, is developing a method to transfer insulin-producing cells to a patient under the skin. Read more.