Medicine by Design’s Grand Questions Program aims to change the future of regenerative medicine through research that addresses some of the field’s biggest unanswered questions.
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Through this program, Medicine by Design is investing in bold ideas and developing transformative and revolutionary solutions that will be of critical importance to regenerative medicine over the next 20 years. These solutions will enable new therapies that promise dramatically better health outcomes for people around the world, ensuring Toronto and Canada continue to lead this health-care transformation.
Medicine by Design is investing $3 million in the Grand Questions Program over the period of spring 2021- spring 2023.
Watch the Grand Questions announcement and panel recording
On May 7, 2021, Medicine by Design hosted an event to announce the funded projects. The event featured a panel discussion called, Ambitious and provocative — expanding the frontiers of regenerative medicine.
Grand Questions Funded Projects
Grand Question: Designing Tissues de novo — Can we make tissues that perform better than nature?
Project: Establishing a ‘Centre for the Design of Novel Human Tissues’ to address graft cell death and promote ‘super-tissue’ development
Michael Garton, Assistant Professor, Institute of Biomedical Engineering, University of Toronto
Michael Laflamme, University Health Network
Yun Li, The Hospital for Sick Children
Maria Cristina Nostro, University Health Network
Shinichiro Ogawa, University Health Network
Stephanie Protze, University Health Network
Bruce Conklin, University of California San Francisco
Martin Fussenegger, ETH Zürich
Ron Weiss, Massachusetts Institute of Technology
Grand Question: Physics of Regeneration — What are the core physio-chemical principles governing organ formation, and can they facilitate organ regeneration?
Project: Defining biophysical mechanisms of organogenesis to facilitate regeneration
Sevan Hopyan, Orthopaedic Surgeon and Senior Scientist, The Hospital for Sick Children
Sidhartha Goyal, University of Toronto
Yu Sun, University of Toronto
Rudolf Winklbauer, University of Toronto
Eric Siggia, The Rockefeller University
Grand Question: New Technology for Cell Tracking — Can we record the signaling history of a cell?
Project: Logging cell experience to learn how to program cell function
Alison McGuigan, Professor, Department of Chemical Engineering and Applied Chemistry and Institute of Biomedical Engineering, University of Toronto
Gary Bader, University of Toronto
Leo Chou, University of Toronto
Michael Garton, University of Toronto
Hartland Jackson, Sinai Health
Tracy McGaha, University of Toronto
Andrew Woolley, University of Toronto
Fei Chen, Massachusetts Institute of Technology
Trey Ideker, University of California San Diego
Harris Wang, Columbia University
Grand Question: Affordability and Accessibility — How can we make regenerative medicine available to everyone?
Project: On-demand cell therapies for affordable patient access in Canada
Keith Pardee, Assistant Professor, Leslie Dan Faculty of Pharmacy, University of Toronto
Leo Chou, University of Toronto
Shana Kelley, University of Toronto
Teodor Veres, University of Toronto, National Research Council Canada
Laszlo Radvanyi, Ontario Institute for Cancer Research
Wilson Wong, Boston University