Special Seminar: Dr. Timothy O’Brien, National University of Ireland, Galway

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Timothy O’Brien, MD, PhD will give a talk titled “Therapeutic Potential of Mesenchymal Stem Cells for Diabetic Complications: Translational Pathway in the EU.”


Diabetes mellitus is assuming pandemic proportions and is associated with microvascular and macrovascular complications which result in major morbidity and mortality. These conditions represent unmet medical need and new treatment approaches are needed. My laboratory is interested in the use of mesenchymal stromal cells to treat diabetic complications as they are readily isolated, can be culture expanded under GMP conditions and possess anti-inflammatory, immunomodulatory and angiogenic properties. We are particularly interested in the translation of laboratory discoveries to the clinic and to this end have constructed specialized GMP and clinical research facilities. The presentation will describe the translational pathway, with an emphasis on regulatory issues, in progressing from the laboratory to early phase clinical trials. Pre-clinical and early clinical trial experience of the use of MSCs in diabetic macrovascular and microvascular disease will be presented. Advances in cell manufacture will also be described.


Dr. O’Brien is Professor of Medicine and Director of the Regenerative Medicine Institute, National University of Ireland Galway. He is also a Consultant Physician in Endocrinology and Metabolism, Saolta University Healthcare Group, Ireland.

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