The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians.
Medicine by Design, in partnership with the Ontario Institute for Regenerative Medicine, is pleased to welcome Cole DeForest, PhD, an assistant professor in the Department of Chemical Engineering and core faculty at the Institute of Stem Cell & Regenerative Medicine at the University of Washington. He will give a talk titled, “User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate.”
The extracellular matrix directs stem cell function through a complex choreography of biomacromolecular interactions in a tissue-dependent manner. Far from static, this hierarchical milieu of biochemical and biophysical cues presented within the native cellular niche is both spatially complex and ever changing. As these pericellular reconfigurations are vital for tissue morphogenesis, disease regulation, and healing, in vitro culture platforms that recapitulate such dynamic environmental phenomena would be invaluable for fundamental studies in stem cell biology, as well as in the eventual engineering of functional human tissue. In this talk, I will discuss some of our group’s recent success in reversibly modifying both the chemical and physical aspects of synthetic cell culture platforms with user-defined spatiotemporal control. Results will highlight our ability to modulate intricate cellular behavior including stem cell differentiation, protein secretion, and cell-cell interactions in 4D.
Learn more about Cole DeForest